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      "ylabel": "Constructed gene mean",
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  ],
  "title": "More cells do not replace independent donors or composition control",
  "assumptions": "Independent balanced nested variances donor1,organoid0.5,cell4; K=3. Separate cell-type means fixed1 and3. No cells or biological samples.",
  "worked": "J=6,K=3时m趋大方差仍为1/6+0.5/18。第一类比例0.3变0.7，总体表达2.4变1.6，类型内均值不变。",
  "checks": {
    "variance_floor_J6_K3": 0.19444444444444442,
    "bulk_pi03": 2.4,
    "bulk_pi07": 1.6
  },
  "generator_source_sha256": {
    "ops/datacenter/editorial_guides/horizons_figures.py": "5ed0031cf4cbcfb7d2d78b4385c8c29200a8312d53744507241da3ca5ca44a9c",
    "ops/datacenter/editorial_guides/deep_figures.py": "158969d9b1f5a4bd13906cf78dd71affc2692df9194593918059d861a6f59c85"
  },
  "source_ids": [
    "h-assembloid2017",
    "h-organoid2024"
  ],
  "formula_source": "Article equations and this versioned script",
  "diagram_nodes": [
    "Independent donors",
    "Organoid batches",
    "Cell composition",
    "Developmental alignment",
    "Functional assays",
    "Cross-protocol validation"
  ]
}