Living systems · v5
Recording Development without Rewriting It: The Information Limits of Cellular Lineage Tracing
A lineage recorder is a noisy communication channel operating in a developing organism.
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170 Chinese and English research reviews connecting primary studies, mathematical models and inspectable evidence.
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Health and measurement · v5
Finding a Rare Signal: The Statistical Architecture of Blood-Based Cancer Detection
Rare-disease screening is governed by denominators as much as by assay sensitivity.
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Health and measurement · v5
The Tumor Is Not a Sample: Spatial Evolution, Detection Limits and Longitudinal Inference
A biopsy observes a region, a sequencing assay observes molecules, and circulating DNA observes a shedding-weighted mixture.
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Health and measurement · v5
Beyond Encapsulation: The Multistage Transport Problem of Messenger RNA Delivery
Messenger RNA delivery is a sequence of conditional transport and reaction steps.
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Health and measurement · v5
Recognition Is Only the Beginning: Engineering Cell Therapies across Solid-Tumor Barriers
Solid-tumor cell therapy must cross barriers to access, recognition and sustained function.
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Health and measurement · v5
From Related Genomes to Transmission Histories: What Pathogen Sequencing Can Establish
Pathogen genomes constrain outbreak histories but do not directly reveal who infected whom.
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Planetary change · v5
Closing the Methane Budget: Atmospheric Inversions, Intermittent Sources and Independent Validation
Atmospheric methane measurements observe concentrations after transport, whereas inventories describe emissions at sources.
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Planetary change · v5
When Water Returns but Storage Does Not: Groundwater Depletion and Irreversible Compaction
Groundwater level, water storage and aquifer storage capacity are related but distinct quantities.
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Planetary change · v5
The Geometry of Ice-Sheet Instability: Grounding Lines, Feedbacks and Forecast Horizons
Marine ice-sheet instability is a geometric feedback, not a date on a forecast calendar.
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Planetary change · v5
A Moving Ocean Baseline: Marine Heatwaves, Attribution and Ecological Exposure
Marine heatwaves are defined relative to a baseline, but organisms experience absolute temperature histories.
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Planetary change · v5
Reading an Ocean Circulation: AMOC Observations, Proxy Ambiguity and Early-Warning Claims
The Atlantic overturning circulation is inferred through direct arrays, hydrographic sections and indirect proxies that do not measure identical quantities.
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Materials and resources · v5
Harvesting Water from Dry Air: Sorption Thermodynamics, Cycling and Delivered Yield
An atmospheric water harvester must adsorb, release, condense and collect water repeatedly.
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